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To integrate Python with InterSystems IRIS, you need to install the intersystems_irispython package using pip and then import the iris module in your Python source code. This allows you to establish a connection to IRIS and perform operations using the IRIS object. You can create a connection using the iris.connect() method with the necessary connection parameters such as hostname, port, namespace, username, and password. Once connected, you can instantiate the IRIS object using iris.createIRIS(conn) and proceed with various operations like setting and killing globals, accessing IRIS classes, and running SQL commands [1][2][3].